InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RREB1

Summary

InnateDB Gene

IDBG-59362.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RREB1

Gene Name

ras responsive element binding protein 1

Synonyms

FINB; HNT; LZ321; RREB-1; Zep-1

Species

Homo sapiens

Ensembl Gene

ENSG00000124782

Encoded Proteins

IDBP-59364

ras responsive element binding protein 1

IDBP-59366

ras responsive element binding protein 1

IDBP-59368

ras responsive element binding protein 1

IDBP-59370

ras responsive element binding protein 1

IDBP-484518

ras responsive element binding protein 1

IDBP-475043

ras responsive element binding protein 1

IDBP-476852

ras responsive element binding protein 1

IDBP-483821

ras responsive element binding protein 1

IDBP-810058

ras responsive element binding protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:7107597-7251980

Strand

Forward strand

Band

p24.3

Transcripts

ENST00000379938	ENSP00000369270
ENST00000379933	ENSP00000369265
ENST00000349384	ENSP00000305560
ENST00000334984	ENSP00000335574
ENST00000491191	ENSP00000420519
ENST00000471433	ENSP00000420299
ENST00000467782	ENSP00000420571
ENST00000475946
ENST00000483150	ENSP00000419511
ENST00000611109	ENSP00000483108

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0046872	metal ion binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007265	Ras protein signal transduction
GO:0007275	multicellular organismal development
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016604	nuclear body
GO:0016607	nuclear speck
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000039087

View Gene Order

ENSBTAG00000005980

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.298248 Hs.687210

RefSeq

NM_001003698 NM_001003699 NM_001003700 NM_001168344 XM_005249272 XM_005249275 XM_005249276 XM_006715156 XM_006715157 XM_006715158 XM_006715159 XM_006715160 XM_006715161

HUGO

OMIM

CCDS

CCDS34335 CCDS34336 CCDS54963

HPRD

03733

IMGT

EMBL

GenPept

RNA Seq Atlas