Version 5.4
Homo sapiens Protein: CTSF
Summary
InnateDB Protein IDBP-59420.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTSF
Protein Name cathepsin F
Synonyms CATSF; CLN13;
Species Homo sapiens
Ensembl Protein ENSP00000310832
InnateDB Gene IDBG-59418 (CTSF)
Protein Structure
UniProt Annotation
Function Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
Subcellular Localization Lysosome.
Disease Associations Ceroid lipofuscinosis, neuronal, 13 (CLN13) [MIM:615362]: A form of neuronal ceroid lipofuscinosis characterized by adult onset of progressive cognitive decline and motor dysfunction leading to dementia and often early death. Some patients develop seizures. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material. {ECO:0000269PubMed:23297359}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity High expression levels in heart, skeletal muscle, brain, testis and ovary; moderate levels in prostate, placenta, liver and colon; and no detectable expression in peripheral leukocytes and thymus.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0008219 cell death
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Cellular Component
GO:0005764 lysosome
GO:0043202 lysosomal lumen
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000668 Peptidase C1A, papain C-terminal
IPR013201 Proteinase inhibitor I29, cathepsin propeptide
PFAM PF00112
PF08246
PRINTS PR00705
PIRSF
SMART SM00645
SM00848
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UBX1
PhosphoSite PhosphoSite-Q9UBX1
TrEMBL E9PSC2
UniProt Splice Variant
Entrez Gene 8722
UniGene Hs.11590
RefSeq NP_003784
HUGO HGNC:2531
OMIM 603539
CCDS CCDS8144
HPRD 04643
IMGT
EMBL AF071748 AF071749 AF088886 AF132894 AF136279 AJ007331 AK313657 AL137742 AP002748 BC011682 BC036451 CH471076
GenPept AAC78838 AAC78839 AAD26616 AAD41790 AAF13146 AAH11682 AAH36451 BAG36411 CAB42883 CAB70900 EAW74547 EAW74548

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca