Version 5.4
| Homo sapiens Gene: CTSF | |||||||
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| Summary | |||||||
| InnateDB Gene | IDBG-59418.6 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | CTSF | ||||||
| Gene Name | cathepsin F | ||||||
| Synonyms | CATSF; CLN13 | ||||||
| Species | Homo sapiens | ||||||
| Ensembl Gene | ENSG00000174080 | ||||||
| Encoded Proteins |
cathepsin F
cathepsin F
cathepsin F
cathepsin F
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| Protein Structure | |||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||
| Entrez Gene | |||||||
| Summary |
Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||
| Type | Protein coding | ||||||
| Genomic Location | Chromosome 11:66563463-66568841 | ||||||
| Strand | Reverse strand | ||||||
| Band | q13.2 | ||||||
| Transcripts | |||||||
| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||
| NETPATH | |||||||
| REACTOME |
MHC class II antigen presentation pathway
Adaptive Immune System pathway
Immune System pathway
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| KEGG |
Lysosome pathway
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| INOH | |||||||
| PID NCI | |||||||
| Cross-References | |||||||
| SwissProt | |||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 8722 | ||||||
| UniGene | Hs.11590 | ||||||
| RefSeq | NM_003793 | ||||||
| HUGO | HGNC:2531 | ||||||
| OMIM | 603539 | ||||||
| CCDS | CCDS8144 | ||||||
| HPRD | 04643 | ||||||
| IMGT | |||||||
| EMBL | |||||||
| GenPept | |||||||
| RNA Seq Atlas | 8722 | ||||||