InnateDB Protein
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IDBP-594208.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ST3GAL4
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Protein Name
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ST3 beta-galactoside alpha-2,3-sialyltransferase 4
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Synonyms
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CGS23; NANTA3; SAT3; SIAT4; SIAT4C; ST3GalIV; STZ;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000433318
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InnateDB Gene
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IDBG-75840 (ST3GAL4)
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Protein Structure
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Function |
It may catalyze the formation of the NeuAc-alpha-2,3- Gal-beta-1,3-GalNAc- or NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant. Also acts on the corresponding 1,3- galactosyl derivative. {ECO:0000269PubMed:8611500}.
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Subcellular Localization |
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid.
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Disease Associations |
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Tissue Specificity |
Highly expressed in adult placenta, ovary and testes.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0008373
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sialyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001675
Glycosyl transferase, family 29
IPR012163
Sialyltransferase
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PFAM |
PF00777
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PRINTS |
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PIRSF |
PIRSF005557
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q11206
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PhosphoSite |
PhosphoSite-Q11206
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TrEMBL |
E9PQZ2
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UniProt Splice Variant |
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Entrez Gene |
6484
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UniGene |
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RefSeq |
XP_005271707
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HUGO |
HGNC:10864
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OMIM |
104240
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CCDS |
CCDS58193
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HPRD |
00084
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IMGT |
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EMBL |
AF035249
AF516603
AF516604
AK291577
AP000806
AP001318
AY040826
BC010645
L23767
X74570
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GenPept |
AAA16460
AAC14162
AAH10645
AAK93790
AAM66432
AAM66433
BAF84266
CAA52662
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