Version 5.4
Homo sapiens Gene: ST3GAL4
Summary
InnateDB Gene IDBG-75840.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ST3GAL4
Gene Name ST3 beta-galactoside alpha-2,3-sialyltransferase 4
Synonyms CGS23; NANTA3; SAT3; SIAT4; SIAT4C; ST3GalIV; STZ
Species Homo sapiens
Ensembl Gene ENSG00000110080
Encoded Proteins
IDBP-75842
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
IDBP-75844
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
IDBP-245177
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
IDBP-384575
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
IDBP-384576
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
IDBP-602074
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
IDBP-594990
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
IDBP-600305
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
IDBP-594208
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
IDBP-601798
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
IDBP-595314
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
IDBP-592863
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
IDBP-599703
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
IDBP-584149
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
IDBP-591105
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
IDBP-588395
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the glycosyltransferase 29 family, a group of enzymes involved in protein glycosylation. The encoded protein is targeted to Golgi membranes but may be proteolytically processed and secreted. The gene product may also be involved in the increased expression of sialyl Lewis X antigen seen in inflammatory responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:126355640-126440344
Strand Forward strand
Band q24.2
Transcripts
ENST00000227495 ENSP00000227495
ENST00000356132 ENSP00000348451
ENST00000392669 ENSP00000376437
ENST00000444328 ENSP00000394354
ENST00000449406 ENSP00000399444
ENST00000534733 ENSP00000433495
ENST00000531217 ENSP00000432929
ENST00000530591 ENSP00000433989
ENST00000534083 ENSP00000433318
ENST00000528605
ENST00000526311 ENSP00000432647
ENST00000528858 ENSP00000432424
ENST00000534452 ENSP00000434756
ENST00000526756
ENST00000526727 ENSP00000436047
ENST00000532243 ENSP00000434349
ENST00000534457 ENSP00000434668
ENST00000524834
ENST00000524860 ENSP00000431170
ENST00000533826
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
GO:0005515 protein binding
GO:0008373 sialyltransferase activity
GO:0047288 monosialoganglioside sialyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006486 protein glycosylation
GO:0016266 O-glycan processing
GO:0018146 keratan sulfate biosynthetic process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0030203 glycosaminoglycan metabolic process
GO:0042339 keratan sulfate metabolic process
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0044281 small molecule metabolic process
GO:0050890 cognition
GO:0097503 sialylation
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030173 integral component of Golgi membrane
GO:0032580 Golgi cisterna membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032038
View Gene Order
ENSBTAG00000016506
Not yet available
Pathways
NETPATH
REACTOME
REACT_118798
Pre-NOTCH Processing in Golgi pathway
REACT_25085
N-Glycan antennae elongation pathway
REACT_25046
Transport to the Golgi and subsequent modification pathway
REACT_115835
Termination of O-glycan biosynthesis pathway
REACT_115606
O-linked glycosylation of mucins pathway
REACT_22433
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_121120
Keratan sulfate biosynthesis pathway
REACT_147853
Mucopolysaccharidoses pathway
REACT_22161
Post-translational protein modification pathway
REACT_118744
Pre-NOTCH Expression and Processing pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_267711
Defective B4GALT7 causes EDS, progeroid type pathway
REACT_267713
Defective CHST6 causes MCDC1 pathway
REACT_121288
Keratan sulfate/keratin metabolism pathway
REACT_147719
MPS VI - Maroteaux-Lamy syndrome pathway
REACT_267645
Defective PAPSS2 causes SEMD-PA pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_147749
MPS IIID - Sanfilippo syndrome D pathway
REACT_25208
N-glycan antennae elongation in the medial/trans-Golgi pathway
REACT_22387
Synthesis of substrates in N-glycan biosythesis pathway
REACT_267662
Defective SLC26A2 causes chondrodysplasias pathway
REACT_111102
Signal Transduction pathway
REACT_200727
O-linked glycosylation pathway
REACT_200874
Sialic acid metabolism pathway
REACT_147739
MPS IX - Natowicz syndrome pathway
REACT_267674
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
REACT_17015
Metabolism of proteins pathway
REACT_267642
Defective CHST14 causes EDS, musculocontractural type pathway
REACT_147798
MPS IV - Morquio syndrome B pathway
REACT_267659
Defective B3GAT3 causes JDSSDHD pathway
REACT_267708
Defective CHST3 causes SEDCJD pathway
REACT_147825
MPS IV - Morquio syndrome A pathway
REACT_267654
Defective EXT2 causes exostoses 2 pathway
REACT_267707
Diseases associated with glycosaminoglycan metabolism pathway
REACT_147734
MPS II - Hunter syndrome pathway
REACT_299
Signaling by NOTCH pathway
REACT_267635
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
REACT_121315
Glycosaminoglycan metabolism pathway
REACT_267705
Diseases of glycosylation pathway
REACT_147759
MPS VII - Sly syndrome pathway
REACT_267682
Defective CHSY1 causes TPBS pathway
REACT_111217
Metabolism pathway
REACT_147857
MPS I - Hurler syndrome pathway
REACT_147753
MPS IIIA - Sanfilippo syndrome A pathway
REACT_147860
MPS IIIC - Sanfilippo syndrome C pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
REACT_147788
MPS IIIB - Sanfilippo syndrome B pathway
KEGG
hsa00601
Glycosphingolipid biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001254757 NM_001254758 NM_001254759 NM_006278 XM_005271649 XM_005271650 XM_005271651 XM_006718896 XM_006718897
HUGO
OMIM
CCDS CCDS58193 CCDS58194 CCDS8474
HPRD 00084
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca