InnateDB Protein
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IDBP-594328.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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EEF1D
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Protein Name
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eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
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Synonyms
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EF-1D; EF1D; FP1047;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000431763
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InnateDB Gene
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IDBG-38640 (EEF1D)
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Protein Structure
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Function |
Isoform 1: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1- alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.Isoform 2: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).
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Subcellular Localization |
Isoform 2: Nucleus {ECO:0000269PubMed:21597468}.
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Disease Associations |
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Tissue Specificity |
Isoform 2 is specifically expressed in brain, cerebellum and testis.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 84 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
84
[view]
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Protein-Protein |
84
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR014038
Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange
IPR018940
Elongation factor 1 beta central acidic region, eukaryote
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PFAM |
PF00736
PF10587
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PRINTS |
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PIRSF |
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SMART |
SM00888
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TIGRFAMs |
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Modification |
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SwissProt |
P29692
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PhosphoSite |
PhosphoSite-P29692
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TrEMBL |
E9PQC9
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UniProt Splice Variant |
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Entrez Gene |
1936
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UniGene |
Hs.732724
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RefSeq |
NP_001123528
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HUGO |
HGNC:3211
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OMIM |
130592
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CCDS |
CCDS47930
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HPRD |
00560
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IMGT |
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EMBL |
AC067930
AK293339
BC007847
BC009907
BC012819
BC062535
BC094806
BT007242
CH471162
Z21507
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GenPept |
AAH07847
AAH09907
AAH12819
AAH62535
AAH94806
AAP35906
BAG56855
CAA79716
EAW82227
EAW82228
EAW82229
EAW82230
EAW82232
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