InnateDB Protein
|
IDBP-59459.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
XRN1
|
Protein Name
|
5'-3' exoribonuclease 1
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000264951
|
InnateDB Gene
|
IDBG-59457 (XRN1)
|
Protein Structure
|
|
Function |
Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). {ECO:0000250, ECO:0000269PubMed:18172165}.
|
Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:12515382, ECO:0000269PubMed:14580940, ECO:0000269PubMed:9802570}. Note=Discrete foci at the inner surface of the cell membrane.
|
Disease Associations |
|
Tissue Specificity |
Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines. {ECO:0000269PubMed:12426100}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
74
[view]
|
Protein-Protein |
74
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
GO:0000288
|
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
|
GO:0000956
|
nuclear-transcribed mRNA catabolic process
|
GO:0010467
|
gene expression
|
GO:0016070
|
RNA metabolic process
|
GO:0016071
|
mRNA metabolic process
|
GO:0016075
|
rRNA catabolic process
|
GO:0043928
|
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
|
GO:0071028
|
nuclear mRNA surveillance
|
GO:0071044
|
histone mRNA catabolic process
|
GO:0090305
|
nucleic acid phosphodiester bond hydrolysis
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR004859
Putative 5-3 exonuclease
IPR016494
5\'-3\' exoribonuclease 1
IPR029060
PIN domain-like
|
PFAM |
PF03159
|
PRINTS |
|
PIRSF |
PIRSF006743
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8IZH2
|
PhosphoSite |
PhosphoSite-Q8IZH2
|
TrEMBL |
C9JCZ8
|
UniProt Splice Variant |
|
Entrez Gene |
54464
|
UniGene |
Hs.629790
|
RefSeq |
NP_061874
|
HUGO |
HGNC:30654
|
OMIM |
607994
|
CCDS |
CCDS3123
|
HPRD |
10470
|
IMGT |
|
EMBL |
AC023508
AC109992
AK096177
AL133623
AY137776
BC039314
BC048104
BX640905
CR627396
CR749518
|
GenPept |
AAH39314
AAH48104
AAN11306
BAC04718
CAB63749
CAE45950
CAH10490
CAH18332
|
|
|