InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DHX34

Summary

InnateDB Protein

IDBP-59488.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DHX34

Protein Name

DEAH (Asp-Glu-Ala-His) box polypeptide 34

Synonyms

DDX34; HRH1;

Species

Homo sapiens

Ensembl Protein

ENSP00000331907

InnateDB Gene

IDBG-59484 (DHX34)

Protein Structure

UniProt Annotation

Function

Probable ATP-binding RNA helicase.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004386	helicase activity
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000956	nuclear-transcribed mRNA catabolic process
GO:2000623	negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

Cellular Component

GO:0005575	cellular_component
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR007502 Helicase-associated domain
IPR011545 DEAD/DEAH box helicase domain
IPR011709 Domain of unknown function DUF1605
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF04408
PF00270
PF07717

PRINTS

PIRSF

SMART

SM00490
SM00847
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14147