Version 5.4
Homo sapiens Protein: VEZT
Summary
InnateDB Protein IDBP-594955.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VEZT
Protein Name vezatin, adherens junctions transmembrane protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000449346
InnateDB Gene IDBG-51658 (VEZT)
Protein Structure
UniProt Annotation
Function Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site. {ECO:0000269PubMed:15090598}.
Subcellular Localization Cell membrane; Multi-pass membrane protein. Cell junction, adherens junction. Nucleus. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0017022 myosin binding
Biological Process
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HBM0
PhosphoSite PhosphoSite-Q9HBM0
TrEMBL
UniProt Splice Variant
Entrez Gene 55591
UniGene Hs.601681
RefSeq
HUGO HGNC:18258
OMIM
CCDS
HPRD 11671
IMGT
EMBL AC084879 AC127165 AF216644 AF225417 AF277625 AK001338 AL133113 AL137497 BC064939
GenPept AAG09719 AAG38485 AAG38514 AAH64939 BAA91634 CAB61416 CAB70772

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca