Version 5.4
Homo sapiens Gene: VEZT
Summary
InnateDB Gene IDBG-51658.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VEZT
Gene Name vezatin, adherens junctions transmembrane protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000028203
Encoded Proteins
IDBP-51660
vezatin, adherens junctions transmembrane protein
IDBP-234564
vezatin, adherens junctions transmembrane protein
IDBP-381258
vezatin, adherens junctions transmembrane protein
IDBP-592066
vezatin, adherens junctions transmembrane protein
IDBP-589894
vezatin, adherens junctions transmembrane protein
IDBP-594955
vezatin, adherens junctions transmembrane protein
IDBP-594553
vezatin, adherens junctions transmembrane protein
IDBP-603632
vezatin, adherens junctions transmembrane protein
IDBP-583392
vezatin, adherens junctions transmembrane protein
IDBP-598092
vezatin, adherens junctions transmembrane protein
IDBP-584828
vezatin, adherens junctions transmembrane protein
IDBP-598156
vezatin, adherens junctions transmembrane protein
IDBP-583619
vezatin, adherens junctions transmembrane protein
IDBP-590968
vezatin, adherens junctions transmembrane protein
IDBP-599933
vezatin, adherens junctions transmembrane protein
IDBP-595100
vezatin, adherens junctions transmembrane protein
IDBP-584270
vezatin, adherens junctions transmembrane protein
IDBP-588421
vezatin, adherens junctions transmembrane protein
IDBP-584275
vezatin, adherens junctions transmembrane protein
IDBP-587126
vezatin, adherens junctions transmembrane protein
IDBP-586486
vezatin, adherens junctions transmembrane protein
IDBP-590132
vezatin, adherens junctions transmembrane protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:95217746-95302790
Strand Forward strand
Band q22
Transcripts
ENST00000261219 ENSP00000261219
ENST00000356859
ENST00000397792 ENSP00000380894
ENST00000436874 ENSP00000410083
ENST00000549589
ENST00000550803 ENSP00000449056
ENST00000547611 ENSP00000447891
ENST00000547997 ENSP00000449346
ENST00000549002 ENSP00000449591
ENST00000546557 ENSP00000447080
ENST00000551746
ENST00000548838 ENSP00000448866
ENST00000547484 ENSP00000447010
ENST00000551472 ENSP00000449701
ENST00000551792
ENST00000553063
ENST00000548455 ENSP00000447044
ENST00000546398
ENST00000552031
ENST00000548822 ENSP00000448019
ENST00000549624 ENSP00000448555
ENST00000548245 ENSP00000446666
ENST00000552626
ENST00000552660 ENSP00000447786
ENST00000551039 ENSP00000448738
ENST00000551994 ENSP00000448724
ENST00000549192
ENST00000552821 ENSP00000447633
ENST00000548371 ENSP00000447468
ENST00000550106
ENST00000547894
ENST00000551695
ENST00000551356
ENST00000551311 ENSP00000450009
ENST00000546365
ENST00000551902
ENST00000546445 ENSP00000447151
ENST00000546409
ENST00000552827
ENST00000552306
ENST00000546951
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017022 myosin binding
Biological Process
GO:0016337 single organismal cell-cell adhesion
GO:0043009 chordate embryonic development
Cellular Component
GO:0001669 acrosomal vesicle
GO:0002142 stereocilia ankle link complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036099
View Gene Order
ENSBTAG00000014044
Not yet available
Cross-References
SwissProt Q9HBM0
TrEMBL
UniProt Splice Variant
Entrez Gene 55591
UniGene Hs.24135 Hs.596229 Hs.601681
RefSeq NM_017599 XM_006719477 XM_006719478 XM_006719479 XM_006719480 XM_006719481 XM_006719482 XM_006719483 XM_006719484 XM_006719485 XM_006719486 XM_006719489 XM_006719490
HUGO HGNC:18258
OMIM
CCDS CCDS44954
HPRD 11671
IMGT
EMBL AC084879 AC127165 AF216644 AF225417 AF277625 AK001338 AL133113 AL137497 BC064939
GenPept AAG09719 AAG38485 AAG38514 AAH64939 BAA91634 CAB61416 CAB70772
RNA Seq Atlas 55591

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca