InnateDB Protein
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IDBP-594997.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TAX1BP1
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Protein Name
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Tax1 (human T-cell leukemia virus type I) binding protein 1
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Synonyms
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CALCOCO3; T6BP; TXBP151;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000444811
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InnateDB Gene
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IDBG-10692 (TAX1BP1)
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Protein Structure
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Function |
Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade. {ECO:0000269PubMed:10435631, ECO:0000269PubMed:10920205}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Expressed in all tissues tested.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated |
Total |
38
[view]
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Protein-Protein |
37
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
11 [view]
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Molecular Function |
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Biological Process |
GO:0006915
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apoptotic process
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GO:0032088
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negative regulation of NF-kappaB transcription factor activity
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GO:0032480
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negative regulation of type I interferon production
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GO:0045087
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innate immune response (InnateDB)
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Cellular Component |
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PDB ID |
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InterPro |
IPR012852
Coiled-coil transcriptional coactivator-like
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PFAM |
PF07888
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q86VP1
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PhosphoSite |
PhosphoSite-Q86VP1
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TrEMBL |
C9JBZ7
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UniProt Splice Variant |
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Entrez Gene |
8887
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UniGene |
Hs.707122
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RefSeq |
NP_001193830
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HUGO |
HGNC:11575
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OMIM |
605326
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CCDS |
CCDS43561
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HPRD |
05618
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IMGT |
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EMBL |
AC004549
AC005091
AF090891
AF268075
AK296720
AL136586
BC050358
CR457056
CR533556
U33821
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GenPept |
AAA75595
AAC13359
AAD15412
AAF24016
AAG03025
AAH50358
BAG59309
CAB66521
CAG33337
CAG38587
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