InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HPR

Summary

InnateDB Protein

IDBP-595052.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HPR

Protein Name

haptoglobin

Synonyms

A-259H10.2; HP;

Species

Homo sapiens

Ensembl Protein

ENSP00000441828

InnateDB Gene

IDBG-720810 (HPR)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

In adult liver the amount of HPR mRNA is at the lower limit of detection, therefore the extent of its expression is at most less than 1000-fold that of the HP1F gene. No HPR mRNA can be detected in fetal liver. Expressed in Hep-G2 and leukemia MOLT-4 cell lines. {ECO:0000269PubMed:8945641}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0030492	hemoglobin binding

Biological Process

GO:0006508	proteolysis
GO:0008152	metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0034366	spherical high-density lipoprotein particle
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

InterPro

IPR000436 Sushi/SCR/CCP
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR008292 Haptoglobin
IPR009003 Trypsin-like cysteine/serine peptidase domain

PFAM

PF00084
PF00089

PRINTS

PR00722

PIRSF

PIRSF001137

SMART

SM00032
SM00020

TIGRFAMs

Post-translational Modifications

Modification

Cross-References