Version 5.4
Homo sapiens Protein: ARFGAP2
Summary
InnateDB Protein IDBP-595159.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARFGAP2
Protein Name ADP-ribosylation factor GTPase activating protein 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000434442
InnateDB Gene IDBG-42643 (ARFGAP2)
Protein Structure
UniProt Annotation
Function GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269PubMed:17760859}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:17760859}. Golgi apparatus membrane {ECO:0000269PubMed:17760859}; Peripheral membrane protein {ECO:0000269PubMed:17760859}; Cytoplasmic side {ECO:0000269PubMed:17760859}. Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
Biological Process
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0032312 regulation of ARF GTPase activity
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0000139 Golgi membrane
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR001164 Arf GTPase activating protein
PFAM PF01412
PRINTS PR00405
PIRSF
SMART SM00105
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N6H7
PhosphoSite PhosphoSite-Q8N6H7
TrEMBL B7Z9M7
UniProt Splice Variant
Entrez Gene 84364
UniGene Hs.436204
RefSeq NP_115765
HUGO HGNC:13504
OMIM 606908
CCDS CCDS7926
HPRD 06069
IMGT
EMBL AB073358 AC090589 AK027482 AK315992 AL834337 BC030148 CH471064
GenPept AAH30148 BAB55144 BAE45716 BAH14363 CAD39004 EAW67963 EAW67968

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca