InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD93

Summary

InnateDB Protein

IDBP-59520.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD93

Protein Name

CD93 molecule

Synonyms

C1qR(P); C1QR1; C1qRP; CDw93; dJ737E23.1; ECSM3; MXRA4;

Species

Homo sapiens

Ensembl Protein

ENSP00000246006

InnateDB Gene

IDBG-59518 (CD93)

Protein Structure

UniProt Annotation

Function

Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. Not expressed in cells of lymphoid origin.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001849	complement component C1q binding
GO:0004872	receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0006909	phagocytosis
GO:0016032	viral process
GO:0016337	single organismal cell-cell adhesion
GO:0042116	macrophage activation

Cellular Component

GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016023	cytoplasmic membrane-bounded vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001304 C-type lectin
IPR001881 EGF-like calcium-binding domain
IPR016187 C-type lectin fold
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR016316 Complement component C1q/Thrombomodulin

PFAM

PF00008
PF00059
PF07645

PRINTS

PIRSF

PIRSF001775

SMART

SM00181
SM00034
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt