Version 5.4
Homo sapiens Gene: CD93
Summary
InnateDB Gene IDBG-59518.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD93
Gene Name CD93 molecule
Synonyms C1qR(P); C1QR1; C1qRP; CDw93; dJ737E23.1; ECSM3; MXRA4
Species Homo sapiens
Ensembl Gene ENSG00000125810
Encoded Proteins
IDBP-59520
CD93 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:23079349-23086340
Strand Reverse strand
Band p11.21
Transcripts
ENST00000246006 ENSP00000246006
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001849 complement component C1q binding
GO:0004872 receptor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0006909 phagocytosis
GO:0016032 viral process
GO:0016337 single organismal cell-cell adhesion
GO:0042116 macrophage activation
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027435
View Gene Order
ENSBTAG00000004207
Not yet available
Cross-References
SwissProt Q9NPY3
TrEMBL
UniProt Splice Variant
Entrez Gene 22918
UniGene Hs.708559 Hs.97199
RefSeq NM_012072
HUGO HGNC:15855
OMIM 120577
CCDS CCDS13149
HPRD 00396
IMGT
EMBL AL118508 BC028075 U94333
GenPept AAB53110 AAH28075 CAC00597
RNA Seq Atlas 22918

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca