InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MOAP1

Summary

InnateDB Protein

IDBP-595308.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MOAP1

Protein Name

modulator of apoptosis 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000451594

InnateDB Gene

IDBG-17380 (MOAP1)

Protein Structure

UniProt Annotation

Function

Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. {ECO:0000269PubMed:15949439}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed, with high levels in heart and brain. {ECO:0000269PubMed:19366867}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0001844	protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0043065	positive regulation of apoptotic process
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0097190	apoptotic signaling pathway
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand