InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SSR1

Summary

InnateDB Protein

IDBP-59545.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SSR1

Protein Name

signal sequence receptor, alpha

Synonyms

TRAPA;

Species

Homo sapiens

Ensembl Protein

ENSP00000244763

InnateDB Gene

IDBG-59541 (SSR1)

Protein Structure

UniProt Annotation

Function

TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	47 [view]
Protein-Protein	47 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006412	translation
GO:0006613	cotranslational protein targeting to membrane
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0008284	positive regulation of cell proliferation
GO:0010467	gene expression
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0044267	cellular protein metabolic process