Homo sapiens Protein: PLCZ1 | |||||||||||||||||||||
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Summary | |||||||||||||||||||||
InnateDB Protein | IDBP-595821.3 | ||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
Gene Symbol | PLCZ1 | ||||||||||||||||||||
Protein Name | phospholipase C, zeta 1 | ||||||||||||||||||||
Synonyms | |||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||
Ensembl Protein | ENSP00000445026 | ||||||||||||||||||||
InnateDB Gene | IDBG-21958 (PLCZ1) | ||||||||||||||||||||
Protein Structure | |||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||
Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)- dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg- activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. {ECO:0000250UniProtKB:Q8K4D7, ECO:0000269PubMed:12416999, ECO:0000269PubMed:14697805, ECO:0000269PubMed:15579586, ECO:0000305}. | ||||||||||||||||||||
Subcellular Localization | Nucleus {ECO:0000250UniProtKB:Q8K4D7}. Cytoplasm, perinuclear region {ECO:0000250UniProtKB:Q8K4D7}. Note=Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis (By similarity). {ECO:0000250UniProtKB:Q8K4D7}. | ||||||||||||||||||||
Disease Associations | |||||||||||||||||||||
Tissue Specificity | Expressed specifically in testis. Weakly expressed in pancreatic-duct cells. Up-regulated in pancreatic- duct cells from patients with cystic fibrosis. {ECO:0000269PubMed:12416999, ECO:0000269PubMed:14697805}. | ||||||||||||||||||||
Comments | |||||||||||||||||||||
Interactions | |||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||
PDB ID | |||||||||||||||||||||
InterPro |
IPR000008
C2 domain IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain IPR001192 Phosphoinositide phospholipase C family IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain |
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PFAM |
PF00168
PF00388 PF00387 |
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PRINTS |
PR00360
PR00390 |
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PIRSF | |||||||||||||||||||||
SMART |
SM00239
SM00148 SM00149 |
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TIGRFAMs | |||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||
Modification | |||||||||||||||||||||
Cross-References | |||||||||||||||||||||
SwissProt | Q86YW0 | ||||||||||||||||||||
PhosphoSite | PhosphoSite- | ||||||||||||||||||||
TrEMBL | F5H828 | ||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||
Entrez Gene | 89869 | ||||||||||||||||||||
UniGene | Hs.97542 | ||||||||||||||||||||
RefSeq | |||||||||||||||||||||
HUGO | HGNC:19218 | ||||||||||||||||||||
OMIM | 608075 | ||||||||||||||||||||
CCDS | |||||||||||||||||||||
HPRD | 06996 | ||||||||||||||||||||
IMGT | |||||||||||||||||||||
EMBL | AC087242 AF532185 AK292279 AY035866 BC125067 | ||||||||||||||||||||
GenPept | AAI25068 AAK61372 AAN71895 BAF84968 | ||||||||||||||||||||