InnateDB Protein
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IDBP-595830.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ETV7
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Protein Name
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ets variant 7
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000440592
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InnateDB Gene
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IDBG-84882 (ETV7)
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Protein Structure
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Function |
Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. Isoform A does not seem to have a repressor activity. Isoform C does not seem to have a repressor activity.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
Expressed in hematopoietic tissues.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
|
Protein-Protein |
7
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0000977
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RNA polymerase II regulatory region sequence-specific DNA binding
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GO:0000981
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sequence-specific DNA binding RNA polymerase II transcription factor activity
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GO:0001227
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RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0005515
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protein binding
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GO:0043565
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sequence-specific DNA binding
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0009887
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organ morphogenesis
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GO:0030154
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cell differentiation
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Cellular Component |
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PDB ID |
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InterPro |
IPR000418
Ets domain
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PFAM |
PF00178
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PRINTS |
PR00454
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PIRSF |
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SMART |
SM00413
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y603
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PhosphoSite |
PhosphoSite-Q9Y603
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
51513
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UniGene |
Hs.272398
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RefSeq |
NP_001193970
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HUGO |
HGNC:18160
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OMIM |
605255
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CCDS |
CCDS56422
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HPRD |
16095
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IMGT |
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EMBL |
AF116508
AF116509
AF116510
AF147782
AF175387
AF218235
AF218365
AF218366
AJ276205
AK122796
AK301011
AK303829
BC035853
CH471081
Z84484
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GenPept |
AAD33989
AAD43250
AAD43251
AAD43252
AAF25007
AAF28350
AAF44742
AAF44743
AAH35853
BAG53734
BAG62628
BAG64776
CAC17012
CAI21615
CAI21616
EAX03885
EAX03888
EAX03890
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