Version 5.4
Homo sapiens Gene: ETV7
Summary
InnateDB Gene IDBG-84882.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ETV7
Gene Name ets variant 7
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000010030
Encoded Proteins
IDBP-84884
ets variant 7
IDBP-84886
ets variant 7
IDBP-84888
ets variant 7
IDBP-84890
ets variant 7
IDBP-595830
ets variant 7
IDBP-809512
ets variant 7
IDBP-809513
ets variant 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the ETS family of transcription factors, which is a large group of evolutionarily conserved transcriptional regulators that play an important role in a variety of cellular processes throughout development and differentiation, and are involved in oncogenesis as well. This protein is predominantly expressed in hematopoietic tissues. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene (PMID:11108721).[provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:36354642-36387800
Strand Reverse strand
Band p21.31
Transcripts
ENST00000339796 ENSP00000342260
ENST00000340181 ENSP00000341843
ENST00000373738 ENSP00000362843
ENST00000373737 ENSP00000362842
ENST00000538992 ENSP00000440592
ENST00000615781 ENSP00000481885
ENST00000620358 ENSP00000484485
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0009887 organ morphogenesis
GO:0030154 cell differentiation
Cellular Component
GO:0005634 nucleus
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa04320
Dorso-ventral axis formation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001207035 NM_001207036 NM_001207037 NM_001207038 NM_001207039 NM_001207040 NM_001207041 NM_016135
HUGO
OMIM
CCDS CCDS4819 CCDS56422 CCDS56423 CCDS56424 CCDS56425 CCDS75440 CCDS75441
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca