Version 5.4
Homo sapiens Protein: NXT1
Summary
InnateDB Protein IDBP-59587.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NXT1
Protein Name NTF2-like export factor 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000254998
InnateDB Gene IDBG-59585 (NXT1)
Protein Structure
UniProt Annotation
Function Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5. {ECO:0000269PubMed:10567585, ECO:0000269PubMed:10848583, ECO:0000269PubMed:11259602, ECO:0000269PubMed:19165146}.
Subcellular Localization Nucleus. Nucleus speckle {ECO:0000305}. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 12 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008536 Ran GTPase binding
Biological Process
GO:0006405 RNA export from nucleus
GO:0006611 protein export from nucleus
GO:0006810 transport
Cellular Component
GO:0005622 intracellular
GO:0005643 nuclear pore
GO:0005737 cytoplasm
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID
InterPro IPR002075 Nuclear transport factor 2
IPR018222 Nuclear transport factor 2, eukaryote
PFAM PF02136
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UKK6
PhosphoSite PhosphoSite-Q9UKK6
TrEMBL
UniProt Splice Variant
Entrez Gene 29107
UniGene
RefSeq NP_037380
HUGO HGNC:15913
OMIM 605811
CCDS CCDS13150
HPRD 16159
IMGT
EMBL AF156957 AL096677 BC000759 BC002687 BC003029 BC003410
GenPept AAD54942 AAH00759 AAH02687 AAH03029 AAH03410 CAC03437

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca