InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DGKZ

Summary

InnateDB Protein

IDBP-595938.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DGKZ

Protein Name

diacylglycerol kinase, zeta

Synonyms

DAGK5; DAGK6; DGK-ZETA; hDGKzeta;

Species

Homo sapiens

Ensembl Protein

ENSP00000436291

InnateDB Gene

IDBG-41544 (DGKZ)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001727	lipid kinase activity
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0046872	metal ion binding

Biological Process

GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007596	blood coagulation
GO:0016310	phosphorylation
GO:0016477	cell migration
GO:0030168	platelet activation
GO:0031571	mitotic G1 DNA damage checkpoint
GO:0035556	intracellular signal transduction
GO:0045930	negative regulation of mitotic cell cycle
GO:0046834	lipid phosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0030027	lamellipodium

Protein Structure and Domains

PDB ID

InterPro

IPR000756 Diacylglycerol kinase, accessory domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR002110 Ankyrin repeat
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR020683 Ankyrin repeat-containing domain

PFAM