Version 5.4
Homo sapiens Gene: DGKZ
Summary
InnateDB Gene IDBG-41544.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DGKZ
Gene Name diacylglycerol kinase, zeta
Synonyms DAGK5; DAGK6; DGK-ZETA; hDGKzeta
Species Homo sapiens
Ensembl Gene ENSG00000149091
Encoded Proteins
IDBP-41546
diacylglycerol kinase, zeta
IDBP-41550
diacylglycerol kinase, zeta
IDBP-372375
diacylglycerol kinase, zeta
IDBP-372386
diacylglycerol kinase, zeta
IDBP-372389
diacylglycerol kinase, zeta
IDBP-587311
diacylglycerol kinase, zeta
IDBP-600686
diacylglycerol kinase, zeta
IDBP-589701
diacylglycerol kinase, zeta
IDBP-600792
diacylglycerol kinase, zeta
IDBP-595938
diacylglycerol kinase, zeta
IDBP-594801
diacylglycerol kinase, zeta
IDBP-586429
diacylglycerol kinase, zeta
IDBP-601300
diacylglycerol kinase, zeta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:46332905-46380554
Strand Forward strand
Band p11.2
Transcripts
ENST00000343674 ENSP00000343065
ENST00000318201 ENSP00000320340
ENST00000456247 ENSP00000395684
ENST00000421244 ENSP00000391021
ENST00000454345 ENSP00000412178
ENST00000525242 ENSP00000435332
ENST00000528615 ENSP00000434719
ENST00000531879
ENST00000527674
ENST00000524984 ENSP00000437060
ENST00000532868 ENSP00000436273
ENST00000527911 ENSP00000436291
ENST00000533376 ENSP00000435435
ENST00000525434
ENST00000534215
ENST00000528173
ENST00000524448 ENSP00000435763
ENST00000527903
ENST00000524869 ENSP00000434016
ENST00000529698
ENST00000527211
ENST00000529660
ENST00000534802
ENST00000532941
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001727 lipid kinase activity
GO:0003951 NAD+ kinase activity
GO:0004143 diacylglycerol kinase activity
GO:0004857 enzyme inhibitor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0046872 metal ion binding
Biological Process
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007596 blood coagulation
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0030168 platelet activation
GO:0031571 mitotic G1 DNA damage checkpoint
GO:0035556 intracellular signal transduction
GO:0043086 negative regulation of catalytic activity
GO:0045930 negative regulation of mitotic cell cycle
GO:0046580 negative regulation of Ras protein signal transduction
GO:0046834 lipid phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0030027 lamellipodium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040479
View Gene Order
ENSBTAG00000013636
Not yet available
Pathways
NETPATH
REACTOME
REACT_2202
Effects of PIP2 hydrolysis pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_14797
Signaling by GPCR pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_604
Hemostasis pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
hsa00561
Glycerolipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.502461 Hs.572253
RefSeq NM_001105540 NM_001199266 NM_001199267 NM_001199268 NM_003646 NM_201532 NM_201533 XM_005253179 XM_005253180 XM_005253181 XM_005253182 XM_006718354 XM_006718355
HUGO
OMIM
CCDS CCDS41640 CCDS44579 CCDS44580 CCDS55757 CCDS55758 CCDS55759 CCDS7918
HPRD 03260
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca