Version 5.4
Homo sapiens Protein: RBL2
Summary
InnateDB Protein IDBP-595952.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBL2
Protein Name retinoblastoma-like 2 (p130)
Synonyms P130; Rb2;
Species Homo sapiens
Ensembl Protein ENSP00000444685
InnateDB Gene IDBG-30965 (RBL2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 344 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 347 [view]
Protein-Protein 89 [view]
Protein-DNA 257 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0016568 chromatin modification
GO:0043550 regulation of lipid kinase activity
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002719 Retinoblastoma-associated protein, B-box
IPR002720 Retinoblastoma-associated protein, A-box
IPR013763 Cyclin-like
PFAM PF01857
PF01858
PRINTS
PIRSF
SMART SM00385
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q08999
PhosphoSite PhosphoSite-Q08999
TrEMBL
UniProt Splice Variant
Entrez Gene 5934
UniGene Hs.611879
RefSeq
HUGO HGNC:9894
OMIM 180203
CCDS
HPRD 01576
IMGT
EMBL AC007342 AK304283 BC034490 S67171 U53220 X74594 X76061
GenPept AAB29227 AAC50479 AAH34490 BAH14149 CAA52671 CAA53661

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca