InnateDB Protein
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IDBP-596035.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CMAS
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Protein Name
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cytidine monophosphate N-acetylneuraminic acid synthetase
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000446239
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InnateDB Gene
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IDBG-23331 (CMAS)
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Protein Structure
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Function |
Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:11602804}.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. Expressed in pancreas, kidney, liver, skeletal muscle, lung, placenta, brain, heart, colon, PBL, small intestine, ovary, testis, prostate, thymus and spleen. {ECO:0000269PubMed:11602804}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0008781
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N-acylneuraminate cytidylyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003329
Acylneuraminate cytidylyltransferase
IPR029044
Nucleotide-diphospho-sugar transferases
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PFAM |
PF02348
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8NFW8
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PhosphoSite |
PhosphoSite-Q8NFW8
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TrEMBL |
F5GYM0
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UniProt Splice Variant |
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Entrez Gene |
55907
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UniGene |
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RefSeq |
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HUGO |
HGNC:18290
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OMIM |
603316
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CCDS |
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HPRD |
04501
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IMGT |
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EMBL |
AC007671
AC092862
AF271388
AF397212
AK022927
AL832975
BC016609
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GenPept |
AAF76203
AAH16609
AAM90580
BAB14311
CAH56346
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