InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BRK1

Summary

InnateDB Protein

IDBP-596123.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BRK1

Protein Name

BRICK1, SCAR/WAVE actin-nucleating complex subunit

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000432472

InnateDB Gene

IDBG-545502 (BRK1)

Protein Structure

UniProt Annotation

Function

Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. {ECO:0000269PubMed:18560548}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0032403	protein complex binding
GO:0048365	Rac GTPase binding

Biological Process

GO:0001701	in utero embryonic development
GO:0008284	positive regulation of cell proliferation
GO:0010592	positive regulation of lamellipodium assembly
GO:0016601	Rac protein signal transduction
GO:0030036	actin cytoskeleton organization
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087	innate immune response
GO:0048870	cell motility
GO:0070207	protein homotrimerization
GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation