Version 5.4
Homo sapiens Gene: BRK1
Summary
InnateDB Gene IDBG-545502.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BRK1
Gene Name BRICK1, SCAR/WAVE actin-nucleating complex subunit
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000254999
Encoded Proteins
IDBP-596123
BRICK1, SCAR/WAVE actin-nucleating complex subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:10115592-10127190
Strand Forward strand
Band p25.3
Transcripts
ENST00000530758 ENSP00000432472
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0032403 protein complex binding
GO:0048365 Rac GTPase binding
Biological Process
GO:0001701 in utero embryonic development
GO:0008284 positive regulation of cell proliferation
GO:0010592 positive regulation of lamellipodium assembly
GO:0016601 Rac protein signal transduction
GO:0030036 actin cytoskeleton organization
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087 innate immune response
GO:0048870 cell motility
GO:0070207 protein homotrimerization
GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation
Cellular Component
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0030027 lamellipodium
GO:0031209 SCAR complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033940
View Gene Order
ENSBTAG00000016098
Not yet available
Pathways
NETPATH
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_12529
Signaling by VEGF pathway
REACT_6802
Innate Immune System pathway
REACT_111102
Signal Transduction pathway
REACT_6900
Immune System pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
INOH
PID NCI
erbb1_downstream_pathway
ErbB1 downstream signaling
rac1_pathway
RAC1 signaling pathway
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt Q8WUW1
TrEMBL
UniProt Splice Variant
Entrez Gene 55845
UniGene Hs.731802
RefSeq NM_018462
HUGO HGNC:23057
OMIM 611183
CCDS CCDS54553
HPRD 12818
IMGT
EMBL AF161418 AK312155 AY148219 AY148220 BC001067 BC007929 BC019303 CH471055
GenPept AAF28978 AAH01067 AAH07929 AAH19303 AAN60161 AAN60162 BAG35089 EAW64061
RNA Seq Atlas 55845

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca