InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLEKHG5

Summary

InnateDB Protein

IDBP-596219.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLEKHG5

Protein Name

pleckstrin homology domain containing, family G (with RhoGef domain) member 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000441445

InnateDB Gene

IDBG-87695 (PLEKHG5)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035767	endothelial cell chemotaxis
GO:0043065	positive regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005911	cell-cell junction
GO:0030027	lamellipodium
GO:0030139	endocytic vesicle
GO:0048471	perinuclear region of cytoplasm