Version 5.4
Homo sapiens Protein: CBR1
Summary
InnateDB Protein IDBP-596282.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CBR1
Protein Name carbonyl reductase 1
Synonyms CBR; hCBR1; SDR21C1;
Species Homo sapiens
Ensembl Protein ENSP00000434613
InnateDB Gene IDBG-2911 (CBR1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004090 carbonyl reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0047021 15-hydroxyprostaglandin dehydrogenase (NADP+) activity
GO:0050221 prostaglandin-E2 9-reductase activity
Biological Process
GO:0008152 metabolic process
GO:0017144 drug metabolic process
GO:0019369 arachidonic acid metabolic process
GO:0019371 cyclooxygenase pathway
GO:0030855 epithelial cell differentiation
GO:0042373 vitamin K metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR013968 Polyketide synthase, KR
PFAM PF00106
PF08659
PRINTS PR00080
PR00081
PIRSF PIRSF000126
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P16152
PhosphoSite PhosphoSite-P16152
TrEMBL
UniProt Splice Variant
Entrez Gene 873
UniGene Hs.88778
RefSeq NP_001273718
HUGO HGNC:1548
OMIM 114830
CCDS CCDS68202
HPRD 00267
IMGT
EMBL AB003151 AB124848 AK294142 AK314879 AP000688 AP001724 BC002511 BC015640 BT019843 CH471079 CR541708 EF141836 J04056 M62420
GenPept AAA17881 AAA52070 AAH02511 AAH15640 AAV38646 ABK97430 BAA33498 BAA89424 BAA95508 BAE45940 BAG37394 BAG57468 CAG46509 EAX09754 EAX09755

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca