InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHI3L2

Summary

InnateDB Protein

IDBP-596413.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHI3L2

Protein Name

chitinase 3-like 2

Synonyms

CHIL2; YKL-39; YKL39;

Species

Homo sapiens

Ensembl Protein

ENSP00000432049

InnateDB Gene

IDBG-101027 (CHI3L2)

Protein Structure

UniProt Annotation

Function

Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity. {ECO:0000269PubMed:22742450}.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Highest expression in chondrocytes, followed by synoviocytes, lung and heart. Not detected in spleen, pancreas, and liver. May also be expressed in developing brain and placenta. {ECO:0000269PubMed:8702629}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004568	chitinase activity
GO:0008061	chitin binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006032	chitin catabolic process

Cellular Component

GO:0005615

extracellular space

Protein Structure and Domains

PDB ID

InterPro

IPR001223 Glycoside hydrolase, family 18, catalytic domain
IPR011583 Chitinase II
IPR017853 Glycoside hydrolase, superfamily
IPR029070 Chitinase insertion domain

PFAM

PF00704

PRINTS

PIRSF

SMART

SM00636

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q15782