InnateDB Protein
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IDBP-596485.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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B2M
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Protein Name
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beta-2-microglobulin
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000453350
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InnateDB Gene
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IDBG-9902 (B2M)
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Protein Structure
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Function |
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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Subcellular Localization |
Secreted {ECO:0000269PubMed:1336137, ECO:0000269PubMed:7554280}. Note=Detected in serum and urine.
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Disease Associations |
Hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]: Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. {ECO:0000269PubMed:16549777}. Note=The disease is caused by mutations affecting the gene represented in this entry.Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 188 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
188
[view]
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Protein-Protein |
175
[view]
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Protein-DNA |
9
[view]
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Protein-RNA |
4
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
GO:0001895
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retina homeostasis
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GO:0002474
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antigen processing and presentation of peptide antigen via MHC class I
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GO:0002479
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antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
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GO:0002480
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antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
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GO:0016032
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viral process
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GO:0019221
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cytokine-mediated signaling pathway
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GO:0042590
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antigen processing and presentation of exogenous peptide antigen via MHC class I
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GO:0045087
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innate immune response
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GO:0050690
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regulation of defense response to virus by virus
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GO:0050776
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regulation of immune response
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GO:0060333
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interferon-gamma-mediated signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
IPR003597
Immunoglobulin C1-set
IPR007110
Immunoglobulin-like domain
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PFAM |
PF07654
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PRINTS |
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PIRSF |
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SMART |
SM00407
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TIGRFAMs |
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Modification |
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SwissProt |
P61769
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PhosphoSite |
PhosphoSite-P61769
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TrEMBL |
Q9UM88
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UniProt Splice Variant |
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Entrez Gene |
567
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UniGene |
Hs.623704
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RefSeq |
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HUGO |
HGNC:914
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OMIM |
109700
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CCDS |
CCDS10113
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HPRD |
00189
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IMGT |
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EMBL |
AB021288
AC025270
AC122108
AF072097
AK315776
AY007153
AY187687
BC032589
BC064910
CH471082
CR457066
DQ217933
M17986
M17987
S82300
V00567
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GenPept |
AAA51811
AAD14388
AAD48083
AAG02006
AAH32589
AAH64910
AAO20842
ABB01003
BAA35182
BAG38125
CAA23830
CAG33347
EAW77277
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