InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POLE

Summary

InnateDB Protein

IDBP-596539.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POLE

Protein Name

polymerase (DNA directed), epsilon

Synonyms

CRCS12; FILS; POLE1;

Species

Homo sapiens

Ensembl Protein

ENSP00000445753

InnateDB Gene

IDBG-65706 (POLE)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006260	DNA replication
GO:0006261	DNA-dependent DNA replication

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR006133 DNA-directed DNA polymerase, family B, exonuclease domain
IPR006134 DNA-directed DNA polymerase, family B, multifunctional domain
IPR006172 DNA-directed DNA polymerase, family B
IPR012337 Ribonuclease H-like domain
IPR013697 DNA polymerase epsilon, catalytic subunit A, C-terminal
IPR019288 Predicted 3\'-5\' exonuclease, PolB-like

PFAM

PF03104
PF00136
PF08490
PF10108

PRINTS

PR00106

PIRSF

SMART

SM00486

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt