InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RCE1

Summary

InnateDB Protein

IDBP-59673.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RCE1

Protein Name

RCE1 homolog, prenyl protein peptidase (S. cerevisiae)

Synonyms

FACE2; RCE1A; RCE1B;

Species

Homo sapiens

Ensembl Protein

ENSP00000309163

InnateDB Gene

IDBG-59671 (RCE1)

Protein Structure

UniProt Annotation

Function

Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:19188362}; Multi-pass membrane protein {ECO:0000269PubMed:19188362}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0004222	metalloendopeptidase activity

Biological Process

GO:0006508	proteolysis
GO:0071586	CAAX-box protein processing

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003675 CAAX amino terminal protease

PFAM

PF02517

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y256

PhosphoSite

PhosphoSite-Q9Y256

TrEMBL

E9PKA7

UniProt Splice Variant

Entrez Gene

9986

UniGene

Hs.654972

RefSeq

NP_005124

HUGO

HGNC:13721

OMIM

605385

CCDS

CCDS8151

HPRD

07289

IMGT

EMBL

AF121951 AP000485 BC093726 BC093728 CH471076 Y13835

GenPept

AAD22632 AAH93726 AAH93728 CAB46278 EAW74565 EAW74566