InnateDB Protein
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IDBP-596827.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PIWIL4
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Protein Name
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piwi-like 4 (Drosophila)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000444575
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InnateDB Gene
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IDBG-68329 (PIWIL4)
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Protein Structure
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Function |
Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association. The piRNA process acts upstream of known mediators of DNA methylation. Participates in a piRNA amplification loop. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). May be involved in the chromatin-modifying pathway by inducing 'Lys-9' methylation of histone H3 at some loci. {ECO:0000250, ECO:0000269PubMed:12906857}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. PIWIL2/MILI is required for nuclear localization (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in testis. According to PubMed:17544373, it is ubiquitously expressed. {ECO:0000269PubMed:17544373}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003100
PAZ domain
IPR012337
Ribonuclease H-like domain
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PFAM |
PF02170
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PRINTS |
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PIRSF |
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SMART |
SM00949
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TIGRFAMs |
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Modification |
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SwissProt |
Q7Z3Z4
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PhosphoSite |
PhosphoSite-Q7Z3Z4
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TrEMBL |
F5GX26
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UniProt Splice Variant |
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Entrez Gene |
143689
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UniGene |
Hs.660188
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RefSeq |
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HUGO |
HGNC:18444
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OMIM |
610315
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CCDS |
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HPRD |
11435
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IMGT |
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EMBL |
AB079366
AK093475
AK096837
AK293616
AP000943
BC031060
CR749642
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GenPept |
AAH31060
BAC04179
BAC04873
BAC81341
BAG57076
CAH18436
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