InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CAPN1

Summary

InnateDB Protein

IDBP-597007.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAPN1

Protein Name

calpain 1, (mu/I) large subunit

Synonyms

CANP; CANP1; CANPL1; muCANP; muCL;

Species

Homo sapiens

Ensembl Protein

ENSP00000435272

InnateDB Gene

IDBG-56732 (CAPN1)

Protein Structure

UniProt Annotation

Function

Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:8769305}. Cell membrane {ECO:0000269PubMed:8769305}. Note=Translocates to the plasma membrane upon Ca(2+) binding.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 97 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	97 [view]
Protein-Protein	97 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004198	calcium-dependent cysteine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0006508	proteolysis
GO:0008284	positive regulation of cell proliferation
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001300 Peptidase C2, calpain, catalytic domain
IPR002048 EF-hand domain
IPR022682 Peptidase C2, calpain, large subunit, domain III
IPR022683 Peptidase C2, calpain, domain III
IPR022684 Peptidase C2, calpain family

PFAM

PF00648
PF00036
PF13202
PF13405
PF01067

PRINTS

PR00704

PIRSF

SMART

SM00230
SM00054
SM00720

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt