InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AKAP17A

Summary

InnateDB Protein

IDBP-597160.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKAP17A

Protein Name

A kinase (PRKA) anchor protein 17A

Synonyms

721P; AKAP-17A; CCDC133; CXYorf3; DXYS155E; PRKA17A; SFRS17A; XE7; XE7Y;

Species

Homo sapiens

Ensembl Protein

ENSP00000435479

InnateDB Gene

IDBG-40259 (AKAP17A)

Protein Structure

UniProt Annotation

Function

Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre- mRNA splicing in a PKA-dependent manner. {ECO:0000269PubMed:16982639, ECO:0000269PubMed:19840947}.

Subcellular Localization

Nucleus speckle {ECO:0000269PubMed:16982639, ECO:0000269PubMed:19840947}.

Disease Associations

Tissue Specificity

Widely expressed. Found in heart, brain, lung, liver, skeletal muscle, kidney and pancreas. Expressed in activated B-cells and placenta. Expressed in all cell lines tested including Jurkat-TAg, U-937 and HEK293 cells. {ECO:0000269PubMed:19840947}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0051018	protein kinase A binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006397	mRNA processing
GO:0007165	signal transduction
GO:0008380	RNA splicing
GO:0042113	B cell activation
GO:0043484	regulation of RNA splicing