InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITPR1

Summary

InnateDB Protein

IDBP-597193.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITPR1

Protein Name

inositol 1,4,5-trisphosphate receptor, type 1

Synonyms

ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94; SCA15; SCA16; SCA29;

Species

Homo sapiens

Ensembl Protein

ENSP00000440564

InnateDB Gene

IDBG-14187 (ITPR1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	46 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

Biological Process

GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0034220	ion transmembrane transport
GO:0045087	innate immune response (InnateDB)
GO:0048016	inositol phosphate-mediated signaling
GO:0055085	transmembrane transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000493 Inositol 1,4,5-trisphosphate-binding protein receptor
IPR005821 Ion transport domain
IPR014821 Inositol 1,4,5-trisphosphate/ryanodine receptor
IPR016093 MIR motif

PFAM

PF00520
PF08709
PF02815

PRINTS

PR00779

PIRSF

SMART

SM00472

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt