InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITIH1

Summary

InnateDB Protein

IDBP-597303.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITIH1

Protein Name

inter-alpha (globulin) inhibitor H1

Synonyms

H1P; IATIH; IGHEP1; ITI-HC1; ITIH; SHAP;

Species

Homo sapiens

Ensembl Protein

ENSP00000443847

InnateDB Gene

IDBG-39685 (ITIH1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005509	calcium ion binding
GO:0009982	pseudouridine synthase activity

Biological Process

GO:0001522	pseudouridine synthesis
GO:0009451	RNA modification
GO:0010951	negative regulation of endopeptidase activity
GO:0030212	hyaluronan metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

InterPro

IPR002035 von Willebrand factor, type A
IPR010600 Inter-alpha-trypsin inhibitor heavy chain, C-terminal
IPR020103 Pseudouridine synthase, catalytic domain

PFAM

PF00092
PF06668

PRINTS

PIRSF

SMART

SM00327

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P19827