InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ALKBH3

Summary

InnateDB Protein

IDBP-597400.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALKBH3

Protein Name

alkB, alkylation repair homolog 3 (E. coli)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000436788

InnateDB Gene

IDBG-40555 (ALKBH3)

Protein Structure

UniProt Annotation

Function

Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron. {ECO:0000269PubMed:12486230, ECO:0000269PubMed:12594517, ECO:0000269PubMed:16174769, ECO:0000269PubMed:22055184}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Ubiquitous. Detected in heart, pancreas, skeletal muscle, thymus, testis, ovary, spleen, prostate, small intestine, peripheral blood leukocytes, urinary bladder and colon. {ECO:0000269PubMed:12486230, ECO:0000269PubMed:16174769, ECO:0000269PubMed:17979886}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008198	ferrous iron binding
GO:0031418	L-ascorbic acid binding
GO:0043734	DNA-N1-methyladenine dioxygenase activity

Biological Process

GO:0006281	DNA repair
GO:0006307	DNA dealkylation involved in DNA repair
GO:0008283	cell proliferation
GO:0035552	oxidative single-stranded DNA demethylation