InnateDB Protein
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IDBP-597702.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MSLN
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Protein Name
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mesothelin
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Synonyms
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MPF; SMRP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000442965
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InnateDB Gene
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IDBG-8270 (MSLN)
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Protein Structure
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Function |
Membrane-anchored forms may play a role in cellular adhesion.Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
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Subcellular Localization |
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus.Megakaryocyte-potentiating factor: Secreted.Isoform 3: Secreted.
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Disease Associations |
Note=Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. {ECO:0000269PubMed:15897581}.
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Tissue Specificity |
Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level). {ECO:0000269PubMed:16857795, ECO:0000269PubMed:7665620}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR010335
Mesothelin
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PFAM |
PF06060
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q13421
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PhosphoSite |
PhosphoSite-Q13421
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TrEMBL |
H3BV92
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UniProt Splice Variant |
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Entrez Gene |
10232
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UniGene |
Hs.408488
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RefSeq |
NP_005814
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HUGO |
HGNC:7371
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OMIM |
601051
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CCDS |
CCDS45370
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HPRD |
03030
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IMGT |
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EMBL |
AE006464
AF180951
AL031258
AY743922
BC003512
BC009272
CH471112
D49441
U40434
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GenPept |
AAC50348
AAF01409
AAH03512
AAH09272
AAK61253
AAV87530
BAA08419
CAC37289
EAW85719
EAW85720
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