InnateDB Protein
|
IDBP-597843.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
GPR132
|
Protein Name
|
G protein-coupled receptor 132
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000438094
|
InnateDB Gene
|
IDBG-22992 (GPR132)
|
Protein Structure
|
|
Function |
May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9- hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton- sensing activity. {ECO:0000269PubMed:12586833, ECO:0000269PubMed:19855098, ECO:0000269PubMed:9770487}.
|
Subcellular Localization |
Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface (By similarity). {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Highly expressed in macrophages and hematopoietic tissues rich in lymphocytes, like spleen and thymus. Weakly expressed in heart and lung. In atherosclerotic plaques, expression is observed around the lipid core and at the shoulder region. {ECO:0000269PubMed:12482833}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
0
|
Protein-DNA |
2
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0004930
|
G-protein coupled receptor activity
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like
IPR005388
G2A lysophosphatidylcholine receptor
IPR017452
GPCR, rhodopsin-like, 7TM
|
PFAM |
PF00001
|
PRINTS |
PR00237
PR01563
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9UNW8
|
PhosphoSite |
PhosphoSite-Q9UNW8
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
29933
|
UniGene |
Hs.532504
|
RefSeq |
NP_001265623
|
HUGO |
HGNC:17482
|
OMIM |
606167
|
CCDS |
CCDS9997
|
HPRD |
06936
|
IMGT |
|
EMBL |
AB465599
AB465600
AF083955
AK292142
AK303654
AL512356
BC004555
BC084546
BT007257
CH471061
EU432121
|
GenPept |
AAD47380
AAH84546
AAP35921
ABY87920
BAF84831
BAG64656
BAG84609
BAG84610
EAW81898
|
|
|