InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACTN1

Summary

InnateDB Protein

IDBP-597868.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACTN1

Protein Name

actinin, alpha 1

Synonyms

BDPLT15;

Species

Homo sapiens

Ensembl Protein

ENSP00000439828

InnateDB Gene

IDBG-10222 (ACTN1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 120 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	122 [view]
Protein-Protein	121 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding
GO:0005178	integrin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0017166	vinculin binding
GO:0044325	ion channel binding

Biological Process

GO:0002576	platelet degranulation
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0030198	extracellular matrix organization
GO:0034329	cell junction assembly
GO:0042981	regulation of apoptotic process
GO:0048041	focal adhesion assembly
GO:0051271	negative regulation of cellular component movement
GO:0051764	actin crosslink formation

Cellular Component

GO:0001726	ruffle
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0030018	Z disc
GO:0031093	platelet alpha granule lumen
GO:0031143	pseudopodium
GO:0042995	cell projection
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001715 Calponin homology domain
IPR002017 Spectrin repeat
IPR002048 EF-hand domain
IPR014837 EF-hand, Ca insensitive
IPR018159 Spectrin/alpha-actinin
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain

PFAM