InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ACTN1

Summary

InnateDB Gene

IDBG-10222.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACTN1

Gene Name

actinin, alpha 1

Synonyms

BDPLT15

Species

Homo sapiens

Ensembl Gene

ENSG00000072110

Encoded Proteins

IDBP-10224

actinin, alpha 1

IDBP-59350

actinin, alpha 1

IDBP-241608

actinin, alpha 1

IDBP-373144

actinin, alpha 1

IDBP-583244

actinin, alpha 1

IDBP-597868

actinin, alpha 1

IDBP-589039

actinin, alpha 1

IDBP-592375

actinin, alpha 1

IDBP-600124

actinin, alpha 1

IDBP-594113

actinin, alpha 1

IDBP-590352

actinin, alpha 1

IDBP-601025

actinin, alpha 1

IDBP-599417

actinin, alpha 1

IDBP-594929

actinin, alpha 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:68874143-68979440

Strand

Reverse strand

Band

q24.1

Transcripts

ENST00000193403	ENSP00000193403
ENST00000376839	ENSP00000366035
ENST00000394419	ENSP00000377941
ENST00000438964	ENSP00000414272
ENST00000556083
ENST00000553882
ENST00000555075	ENSP00000452254
ENST00000538545	ENSP00000439828
ENST00000544964	ENSP00000444422
ENST00000553290	ENSP00000450625
ENST00000556432
ENST00000556343
ENST00000555616	ENSP00000450903
ENST00000556433	ENSP00000450764
ENST00000554508
ENST00000554158
ENST00000553370	ENSP00000450925
ENST00000553779	ENSP00000450618
ENST00000556571	ENSP00000452423
ENST00000553659	ENSP00000451086
ENST00000556203

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 120 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	122 [view]
Protein-Protein	121 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding
GO:0003779	actin binding
GO:0005178	integrin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0017166	vinculin binding
GO:0019904	protein domain specific binding
GO:0044325	ion channel binding
GO:0051015	actin filament binding

Biological Process

GO:0002576	platelet degranulation
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0030198	extracellular matrix organization
GO:0034329	cell junction assembly
GO:0042981	regulation of apoptotic process
GO:0048041	focal adhesion assembly
GO:0051017	actin filament bundle assembly
GO:0051271	negative regulation of cellular component movement
GO:0051764	actin crosslink formation

Cellular Component

GO:0001725	stress fiber
GO:0001726	ruffle
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005916	fascia adherens
GO:0005925	focal adhesion
GO:0030018	Z disc
GO:0030864	cortical actin cytoskeleton
GO:0031093	platelet alpha granule lumen
GO:0031143	pseudopodium
GO:0042995	cell projection
GO:0043197	dendritic spine
GO:0070062	extracellular vesicular exosome