InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPR68

Summary

InnateDB Protein

IDBP-598227.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPR68

Protein Name

G protein-coupled receptor 68

Synonyms

GPR12A; OGR1;

Species

Homo sapiens

Ensembl Protein

ENSP00000434045

InnateDB Gene

IDBG-16259 (GPR68)

Protein Structure

UniProt Annotation

Function

Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Found at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system. {ECO:0000269PubMed:12955148}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity

Biological Process

GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0032024	positive regulation of insulin secretion
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0045656	negative regulation of monocyte differentiation
GO:0071467	cellular response to pH
GO:2001206	positive regulation of osteoclast development

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR005389 OGR1 sphingosylphosphorylcholine receptor
IPR005464 Psychosine receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR01564
PR01649

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q15743