InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITCH

Summary

InnateDB Protein

IDBP-598248.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITCH

Protein Name

itchy E3 ubiquitin protein ligase homolog (mouse)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000445608

InnateDB Gene

IDBG-68143 (ITCH)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 211 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	211 [view]
Protein-Protein	210 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0043021	ribonucleoprotein complex binding
GO:0045236	CXCR chemokine receptor binding

Biological Process

GO:0001558	regulation of cell growth
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006915	apoptotic process
GO:0006954	inflammatory response
GO:0007219	Notch signaling pathway
GO:0016567	protein ubiquitination
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032480	negative regulation of type I interferon production
GO:0035519	protein K29-linked ubiquitination
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0046329	negative regulation of JNK cascade
GO:0046718	viral entry into host cell
GO:0050687	negative regulation of defense response to virus
GO:0051607	defense response to virus
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway
GO:0070534	protein K63-linked ubiquitination
GO:0070936	protein K48-linked ubiquitination
GO:0090085	regulation of protein deubiquitination