InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ITCH

Summary

InnateDB Gene

IDBG-68143.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITCH

Gene Name

itchy E3 ubiquitin protein ligase

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000078747

Encoded Proteins

IDBP-68147

itchy E3 ubiquitin protein ligase homolog (mouse)

IDBP-68149

itchy E3 ubiquitin protein ligase homolog (mouse)

IDBP-598248

itchy E3 ubiquitin protein ligase homolog (mouse)

IDBP-808375

itchy E3 ubiquitin protein ligase

IDBP-808377

itchy E3 ubiquitin protein ligase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18246070

ITCH is an E3 ligase that negatively regulates inflammatory signalling pathways by controlling the function of the ubiquitin-editing enzyme TNFAIP3.

PMID 19881509

ITCH is a HECT domain-containing E3 ligase that negatively regulates MAVS-mediated antiviral response by catalyzing the K48-linked polyubiquitination and degradation of MAVS.

PMID 22057290

The E3 ligase ITCH and deubiquitinase CYLD act together to regulate TAK1 and inflammation.

InnateDB Annotation from Orthologs

Summary

PMID 22057290

[Mus musculus] The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation.

Entrez Gene

Summary

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:34363235-34511393

Strand

Forward strand

Band

q11.22

Transcripts

ENST00000262650	ENSP00000262650
ENST00000374864	ENSP00000363998
ENST00000486883
ENST00000479215
ENST00000483727
ENST00000461661
ENST00000535650	ENSP00000445608
ENST00000610336	ENSP00000484783
ENST00000621101	ENSP00000480499

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 211 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	211 [view]
Protein-Protein	210 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0016874	ligase activity
GO:0043021	ribonucleoprotein complex binding
GO:0045236	CXCR chemokine receptor binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0001558	regulation of cell growth
GO:0002669	positive regulation of T cell anergy
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006915	apoptotic process
GO:0006954	inflammatory response
GO:0007219	Notch signaling pathway
GO:0016567	protein ubiquitination
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032480	negative regulation of type I interferon production
GO:0035519	protein K29-linked ubiquitination
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045732	positive regulation of protein catabolic process
GO:0046329	negative regulation of JNK cascade
GO:0046642	negative regulation of alpha-beta T cell proliferation
GO:0046718	viral entry into host cell
GO:0050687	negative regulation of defense response to virus
GO:0051607	defense response to virus
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway
GO:0070534	protein K63-linked ubiquitination
GO:0070936	protein K48-linked ubiquitination
GO:0090085	regulation of protein deubiquitination