Version 5.4
Homo sapiens Protein: MYO18B
Summary
InnateDB Protein IDBP-598691.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYO18B
Protein Name myosin XVIIIB
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000441301
InnateDB Gene IDBG-3049 (MYO18B)
Protein Structure
UniProt Annotation
Function May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth.
Subcellular Localization Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere. Note=Punctate pattern in undifferentiated myoblasts. Nuclear, on primary cardiomyocytes and adult muscle. A partial sarcomeric location was found in some cardiomyocytes.
Disease Associations
Tissue Specificity Selectively expressed in cardiac and skeletal muscles. Weakly expressed in testis, pancreas, placenta, prostate, lung and thymus.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003774 motor activity
GO:0003779 actin binding
GO:0005524 ATP binding
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0016461 unconventional myosin complex
GO:0030017 sarcomere
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IUG5
PhosphoSite PhosphoSite-Q8IUG5
TrEMBL
UniProt Splice Variant
Entrez Gene 84700
UniGene Hs.691493
RefSeq
HUGO HGNC:18150
OMIM 607295
CCDS
HPRD 09529
IMGT
EMBL AB042648 AB075376 AJ271918 AJ310931 AJ310932 AL022329 AL079300 AL080245 AL833890 AY077700 BC144597 BC150626 Z98949
GenPept AAI44598 AAI50627 AAL75811 BAB55550 BAC16363 CAC70712 CAC70714 CAC81082 CAD38746

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca