InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADK

Summary

InnateDB Protein

IDBP-598952.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADK

Protein Name

adenosine kinase

Synonyms

AK;

Species

Homo sapiens

Ensembl Protein

ENSP00000443965

InnateDB Gene

IDBG-79046 (ADK)

Protein Structure

UniProt Annotation

Function

ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.

Subcellular Localization

Isoform 1: Nucleus.Isoform 2: Cytoplasm.

Disease Associations

Hypermethioninemia due to adenosine kinase deficiency (HMAKD) [MIM:614300]: A metabolic disorder characterized by global developmental delay, early-onset seizures, mild dysmorphic features, and characteristic biochemical anomalies, including persistent hypermethioninemia with increased levels of S- adenosylmethionine and S-adenosylhomocysteine. Homocysteine levels are typically normal. {ECO:0000269PubMed:21963049}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed. Highest level in placenta, liver, muscle and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004001	adenosine kinase activity
GO:0005524	ATP binding
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006144	purine nucleobase metabolic process
GO:0009156	ribonucleoside monophosphate biosynthetic process
GO:0016310	phosphorylation
GO:0043101	purine-containing compound salvage
GO:0044209	AMP salvage
GO:0044281	small molecule metabolic process
GO:0055086	nucleobase-containing small molecule metabolic process