InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ADK

Summary

InnateDB Gene

IDBG-79046.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADK

Gene Name

adenosine kinase

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000156110

Encoded Proteins

IDBP-79048

adenosine kinase

IDBP-79050

adenosine kinase

IDBP-598952

adenosine kinase

IDBP-584525

adenosine kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:74151185-74709303

Strand

Forward strand

Band

q22.2

Transcripts

ENST00000286621	ENSP00000286621
ENST00000372734	ENSP00000361819
ENST00000478611
ENST00000467840
ENST00000539909	ENSP00000443965
ENST00000541550	ENSP00000438321

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004001	adenosine kinase activity
GO:0005524	ATP binding
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006144	purine nucleobase metabolic process
GO:0006166	purine ribonucleoside salvage
GO:0006175	dATP biosynthetic process
GO:0009156	ribonucleoside monophosphate biosynthetic process
GO:0010613	positive regulation of cardiac muscle hypertrophy
GO:0016310	phosphorylation
GO:0032922	circadian regulation of gene expression
GO:0042102	positive regulation of T cell proliferation
GO:0043101	purine-containing compound salvage
GO:0044209	AMP salvage
GO:0044281	small molecule metabolic process
GO:0044342	type B pancreatic cell proliferation
GO:0046085	adenosine metabolic process
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000039197

View Gene Order

ENSBTAG00000011072

Not yet available

Pathways

NETPATH

REACTOME

REACT_1923

Purine salvage pathway

REACT_1698

Metabolism of nucleotides pathway

REACT_522

Purine metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa00230

Purine metabolism pathway

INOH

INOH website

Purine nucleotides nucleosides metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.604694 Hs.615071 Hs.656586

RefSeq

NM_001123 NM_001202449 NM_001202450 NM_006721 XM_005269538

HUGO

OMIM

CCDS

CCDS55716 CCDS55717 CCDS7343 CCDS7344

HPRD

00039

IMGT

EMBL

GenPept

RNA Seq Atlas