InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: P2RY6

Summary

InnateDB Protein

IDBP-599149.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P2RY6

Protein Name

pyrimidinergic receptor P2Y, G-protein coupled, 6

Synonyms

P2Y6;

Species

Homo sapiens

Ensembl Protein

ENSP00000443427

InnateDB Gene

IDBG-63719 (P2RY6)

Protein Structure

UniProt Annotation

Function

Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0045028	G-protein coupled purinergic nucleotide receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000371 P2Y3 purinoceptor
IPR001973 P2Y6 purinoceptor
IPR003912 Protease-activated receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR01065
PR01068
PR01428

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q15077